The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers.As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosis, which makes their inhibition an attractive antit
The present work analyzes the use of hybrid joints for the construction of yachts with the purpose of reducing the structural weight.By means of the elaboration of specimens made of tubular steel Toy and fiberglass (GFRP).This is to significantly reduce the weight of the superstructure, allowing the yacht to be lighter.At the same time this reduces
It has been shown that fluid intelligence (gf) is fundamental to overcome interference due to information of a previously encoded item along a task-relevant domain.However, the biasing effect of task-irrelevant dimensions is still unclear as well as its relation with gf.The present study aimed at clarifying these issues.Gf was assessed in 60 health
Bio-inspired optimization techniques (BOT) are part of Hats intelligent computing techniques.There are several BOTs available and many new BOTs are evolving in this era of industrial revolution 4.0.Genetic algorithm, particle swarm optimization, artificial bee colony, and grey wolf optimization are the techniques explored by researchers in the fiel
Australian bat lyssavirus (ABLV) is a recently emerged rhabdovirus of the genus lyssavirus considered endemic in Australian bat populations that causes a neurological disease in people indistinguishable from clinical rabies.There are two distinct variants of ABLV, one that circulates in frugivorous bats (genus Pteropus) and the other in insectivoro